Hemoglobin dendrimers: Functional protein clusters

被引：32

作者：

Kluger, R ^{[1
]}

Zhang, J ^{[1
]}

机构：

[1] Univ Toronto, Dept Chem, Toronto, ON M5S 3H6, Canada

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2003年 / 125卷 / 20期

关键词：

D O I：

10.1021/ja034376z

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A cluster of cross-linked hemoglobin tetramers was prepared by conjugating active esters to amino groups of a starburst dendrimer. Comparison of oxygen-binding properties of the protein cluster to those of nonclustered species reveals an increase in affinity and a decrease in cooperativity in the cluster. The altered oxygen-binding properties are assigned to protein-protein interactions. Copyright © 2003 American Chemical Society.

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页码：6070 / 6071

页数：2

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