Cutaneous ulcerations and pustular psoriasis flare caused by recombinant interferon beta injections in patients with multiple sclerosis

被引：70

作者：

Webster, GF ^{[1
]}

Knobler, RL ^{[1
]}

Lublin, FD ^{[1
]}

Kramer, EM ^{[1
]}

Hochman, LR ^{[1
]}

机构：

[1] JEFFERSON MED COLL,DEPT NEUROL,PHILADELPHIA,PA 19107

来源：

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY | 1996年 / 34卷 / 02期

关键词：

D O I：

10.1016/S0190-9622(07)80010-7

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 [皮肤病与性病学];

摘要：

Seven patients with multiple sclerosis who were receiving subcutaneous injections of recombinant interferon beta had pain followed by ulceration at the injection site. An eighth patient had a pustular flare of her usually mild psoriasis. No evidence of infection or contaminated medication was found.

引用

页码：365 / 367

页数：3

共 8 条

[1]

DIVERGENT IN-VIVO AND IN-VITRO ANTILEUKEMIC ACTIVITY OF RECOMBINANT INTERFERON-BETA IN PATIENTS WITH CHRONIC-PHASE CHRONIC MYELOGENOUS LEUKEMIA [J].

AULITZKY, WE ;

PESCHEL, C ;

DESPRES, D ;

AMAN, J ;

TRAUTMAN, P ;

TILG, H ;

RUDOLF, G ;

HUTTMANN, H ;

OBERMEIER, J ;

HEROLD, M ;

HUBER, C .

ANNALS OF HEMATOLOGY, 1993, 67 (05) :205-211

[2]

THE INTERFERONS - MECHANISMS OF ACTION AND CLINICAL-APPLICATIONS [J].

BARON, S ;

TYRING, SK ;

FLEISCHMANN, WR ;

COPPENHAVER, DH ;

NIESEL, DW ;

KLIMPEL, GR ;

STANTON, GJ ;

HUGHES, TK .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1991, 266 (10) :1375-1383

[3]

TREATMENT OF CHRONIC HEPATITIS-C WITH RECOMBINANT INTERFERON-ALFA - A MULTICENTER RANDOMIZED, CONTROLLED TRIAL [J].

DAVIS, GL ;

BALART, LA ;

SCHIFF, ER ;

LINDSAY, K ;

BODENHEIMER, HC ;

PERRILLO, RP ;

CAREY, W ;

JACOBSON, IM ;

PAYNE, J ;

DIENSTAG, JL ;

VANTHIEL, DH ;

TAMBURRO, C ;

LEFKOWITCH, J ;

ALBRECHT, J ;

MESCHIEVITZ, C ;

ORTEGO, TJ ;

GIBAS, A .

NEW ENGLAND JOURNAL OF MEDICINE, 1989, 321 (22) :1501-1506

[4]

INTERFERON BETA-1B IS EFFECTIVE IN RELAPSING-REMITTING MULTIPLE-SCLEROSIS - CLINICAL-RESULTS OF A MULTICENTER, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL [J].

DUQUETTE, P ;

GIRARD, M ;

DESPAULT, L ;

DUBOIS, R ;

KNOBLER, RL ;

LUBLIN, FD ;

KELLEY, L ;

FRANCIS, GS ;

LAPIERRE, Y ;

ANTEL, J ;

FREEDMAN, M ;

HUM, S ;

GREENSTEIN, JI ;

MISHRA, B ;

MULDOON, J ;

WHITAKER, JN ;

EVANS, BK ;

LAYTON, B ;

SIBLEY, WA ;

LAGUNA, J ;

KRIKAWA, J ;

PATY, DW ;

OGER, JJ ;

KASTRUKOFF, LF ;

MOORE, GRW ;

HASHIMOTO, SA ;

MORRISON, W ;

NELSON, J ;

GOODIN, DS ;

MASSA, SM ;

GUTTERIDGE, E ;

ARNASON, BGW ;

NORONHA, A ;

REDER, AT ;

MARTIA, R ;

EBERS, GC ;

RICE, GPA ;

LESAUX, J ;

JOHNSON, KP ;

PANITCH, HS ;

BEVER, CT ;

CONWAY, K ;

WALLENBERG, JC ;

BEDELL, L ;

VANDENNOORT, S ;

WEINSHENKER, B ;

WEISS, W ;

REINGOLD, S ;

PACHNER, A ;

TAYLOR, W .

NEUROLOGY, 1993, 43 (04) :655-661

[5]

GEORGETSON MJ, 1993, AM J GASTROENTEROL, V88, P1756

[6]

BETA-INTERFERON THERAPY IN PATIENTS WITH POOR-PROGNOSIS KAPOSI-SARCOMA RELATED TO THE ACQUIRED-IMMUNODEFICIENCY-SYNDROME (AIDS) - A PHASE-II TRIAL WITH PRELIMINARY EVIDENCE OF ANTIVIRAL ACTIVITY AND LOW INCIDENCE OF OPPORTUNISTIC INFECTIONS [J].

MILES, SA ;

WANG, HJ ;

CORTES, E ;

CARDEN, J ;

MARCUS, S ;

MITSUYASU, RT .

ANNALS OF INTERNAL MEDICINE, 1990, 112 (08) :582-589

[7]

INTERFERON BETA-1B IS EFFECTIVE IN RELAPSING-REMITTING MULTIPLE-SCLEROSIS .2. MRI ANALYSIS RESULTS OF A MULTICENTER, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL [J].

PATY, DW ;

LI, DKB ;

DUQUETTE, P ;

GIRARD, M ;

DESPAULT, L ;

DUBOIS, R ;

KNOBLER, RL ;

LUBLIN, FD ;

KELLEY, L ;

FRANCIS, GS ;

LAPIERRE, Y ;

ANTEL, J ;

FREEDMAN, M ;

HUM, S ;

GREENSTEIN, JI ;

MISHRA, B ;

MULDOON, J ;

WHITAKER, JN ;

EVANS, BK ;

LAYTON, B ;

SIBLEY, WA ;

LAGUNA, J ;

KRIKAWA, J ;

PATY, DW ;

OGER, JJ ;

KASTRUKOFF, LF ;

MOORE, GRW ;

HASHIMOTO, SA ;

MORRISON, W ;

NELSON, J ;

GOODIN, DS ;

MASSA, SM ;

GUTTERIDGE, E ;

ARNASON, BGW ;

NORONHA, A ;

REDER, AT ;

MARTIA, R ;

EBERS, GC ;

RICE, GPA ;

LESAUX, J ;

JOHNSON, KP ;

PANITCH, HS ;

BEVER, CT ;

CONWAY, K ;

WALLENBERG, JC ;

BEDELL, L ;

VANDENNOORT, S ;

WEINSHENKER, B ;

WEISS, W ;

REINGOLD, S .

NEUROLOGY, 1993, 43 (04) :662-667

[8]

QUESADA JR, 1986, LANCET, V1, P1466

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