The SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognition

被引:916
作者
Gareau, Jaclyn R. [1 ]
Lima, Christopher D. [1 ]
机构
[1] Mem Sloan Kettering Canc Ctr, Struct Biol Program, New York, NY 10021 USA
基金
美国国家卫生研究院;
关键词
NUCLEAR-PORE COMPLEX; E3 LIGASE ACTIVITY; KAPPA-B ACTIVATION; UBIQUITIN LIGASE; STRUCTURAL BASIS; SACCHAROMYCES-CEREVISIAE; BINDING-MOTIF; TRANSCRIPTIONAL REPRESSION; SUBSTRATE RECOGNITION; DEPENDENT ACTIVATION;
D O I
10.1038/nrm3011
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Proteins of the small ubiquitin-related modifier (SUMO) family are conjugated to proteins to regulate such cellular processes as nuclear transport, transcription, chromosome segregation and DNA repair. Recently, numerous insights into regulatory mechanisms of the SUMO modification pathway have emerged. Although SUMO-conjugating enzymes can discriminate between SUMO targets, many substrates possess characteristics that facilitate their modification. Other post-translational modifications also regulate SUMO conjugation, suggesting that SUMO signalling is integrated with other signal transduction pathways. A better understanding of SUMO regulatory mechanisms will lead to improved approaches for analysing the function of SUMO and substrate conjugation in distinct cellular pathways.
引用
收藏
页码:861 / 871
页数:11
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