Association between the monocyte chemoattractant protein-1 -2518G/A gene polymorphism and acute myocardial infarction patients among Egyptian population

The aim of the present study was to investigate the possible association between the -2518G/A polymorphism of the monocyte chemoattractant protein-1 (MCP-1) gene and acute myocardial infarction (MI) in a sample of the Egyptian population. A total of 30 Egyptian patients with coronary artery disease (CAD) manifested as acute myocardial infarction (MI) for the first time and 25 unrelated healthy control individuals were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The proportion of G/A and G/G genotypes were significantly higher in the acute MI group than the control group (P < 0.05). The acute MI patients group showed a significant higher frequency of the G allele compared to the controls (P < 0.05). Analysis of the relationship between the G/A, G/G genotypes and A/A genotype acute MI group regarding the conventional risk factors showed statistical significant difference regarding age, total cholesterol, low-density lipoprotein and high-density lipoprotein (P < 0.05), but there was no significant relationship regarding sex, smoking, history of diabetes mellitus, hypertension, obesity, body mass index (BMI) and triglyceride, but we observed that the percentage of men was higher than the percentage of women in both G/A, G/G genotypes and A/A genotype acute MI patients. Also, among our patients, the percentage of smokers, diabetics, hypertensive, and obesity and the mean of BMI and triglyceride were higher in the G/A, G/G genotypes acute MI patients than that in A/A genotype acute MI patients. In conclusion, our study indicated that there was a significant association between the MCP-1 S2518G/A polymorphism and acute MI in the Egyptian population, but this significant association is dependent on the presence of MI risk factors. Blood Coagul Fibrinolysis 22: 7-13 (C) 2011 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.