Endothelialization of titanium surfaces

被引：38

作者：

Meyers, Steven R.

Hamilton, Paul T.

Walsh, Elisabeth B.

Kenan, Daniel J. ^{[1
]}

Grinstaff, Mark W.

机构：

[1] Duke Univ, Med Ctr, Dept Pathol, Durham, NC 27710 USA

[2] Boston Univ, Dept Biomed Engn, Boston, MA 02215 USA

[3] Boston Univ, Dept Chem, Boston, MA 02215 USA

[4] Affinergy Inc, Durham, NC 27713 USA

[5] Duke Univ, Dept Chem, Durham, NC 27708 USA

来源：

ADVANCED MATERIALS | 2007年 / 19卷 / 18期

关键词：

IMPLANT MATERIALS; PHAGE DISPLAY; ESCHERICHIA-COLI; PEPTIDE LIBRARY; CELL-ADHESION; IN-VITRO; SELECTION; RECEPTOR; BINDING; ANTAGONISTS;

D O I：

10.1002/adma.200700029

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An interfacial peptide coating possessing domains that bind to Ti and endothelial cells is synthesized (see figure). Peptides with specific adherence to Ti are identified using phage display, and the RGD motif was selected for cell binding. The peptide can be applied from aqueous solution and possesses micromolar binding affinities. The coating significantly enhances endothelial cell adhesion and spreading under both static and dynamic conditions.

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页码：2492 / +

页数：8

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