Furazolidone- and nitrofurantoin-resistant Helicobacter pylori:: Prevalence and role of genes involved in metronidazole resistance

被引：45

作者：

Kwon, DH

Lee, M

Kim, JJ

Kim, JG

El-Zaatari, FAK

Osato, MS

Graham, DY

机构：

[1] Vet Affairs Med Ctr, Houston, TX 77030 USA

[2] Baylor Coll Med, Dept Med, Houston, TX 77030 USA

[3] Baylor Coll Med, Div Mol Virol, Houston, TX 77030 USA

[4] Sungkyunkwan Univ, Samsung Med Ctr, Dept Med, Sch Med, Seoul, South Korea

[5] Korea Univ, Guro Hosp, Seoul 136701, South Korea

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2001年 / 45卷 / 01期

关键词：

D O I：

10.1128/AAC.45.1.306-308.2001

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The prevalence of furazolidone, nitrofurantoin, and metranidazole resistance among Helicobacter pylori strains was assessed with 431 clinical isolates. Fifty-two percent were metronidazole resistant, compared to 2% (7 of 431) with resistance to furazolidone and nitrofurantoin. All seven furazolidone and nitrofurantoin-resistant isolates were also metronidazole resistant, rdxA, frxA, and fdxB knockouts did not result in furazolidone or nitrofurantoin resistance. These data suggest that furazolidone and nitrofurantoin may be good alternatives to metronidazole for treating H. pylori infection.

引用

页码：306 / 308

页数：3

共 21 条

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