Methadone, ciprofloxacin, and adverse drug reactions

被引：71

作者：

Herrlin, K ^{[1
]}

Segerdahl, M

Gustafsson, LL

Kalso, E

机构：

[1] Huddinge Univ Hosp, Karolinska Inst, Dept Med Lab Sci & Technol, Div Clin Pharmacol, S-14186 Huddinge, Sweden

[2] Huddinge Univ Hosp, Karolinska Inst, Dept Anaesthesia & Intens Care, Div Pain Management, S-14186 Huddinge, Sweden

来源：

LANCET | 2000年 / 356卷 / 9247期

关键词：

D O I：

10.1016/S0140-6736(00)03409-7

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Ciprofloxacin, given to a patient successfully treated with methadone for more than 6 years, caused profound sedation, confusion, and respiratory depression. We suggest that this was caused by ciprofloxacin inhibition of CYP1A2 and CYP3A4 activity, two of the cytochrome p450 isozymes involved in the metabolism of methadone.

引用

页码：2069 / 2070

页数：2

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