Tumor-Induced Disruption of Proximal TCR-Mediated Signal Transduction in Tumor-Infiltrating CD8+ Lymphocytes Inactivates Antitumor Effector Phase

被引：37

作者：

Vazquez-Cintron, Edwin J. ^{[1
]}

Monu, Ngozi R. ^{[1
,2
]}

Frey, Alan B. ^{[1
]}

机构：

[1] NYU, Langone Med Ctr, Dept Cell Biol, New York, NY 10016 USA

[2] NYU, Langone Med Ctr, New York Univ Canc Inst, New York, NY 10016 USA

来源：

JOURNAL OF IMMUNOLOGY | 2010年 / 185卷 / 12期

基金：

美国国家卫生研究院;

关键词：

T-CELL-ACTIVATION; TRANSMEMBRANE ADAPTER PROTEIN; NATURAL-KILLER-CELLS; TYROSINE-PHOSPHATASE SHP-1; IMMATURE MYELOID CELLS; DENDRITIC CELLS; INHIBITORY RECEPTOR; IN-VIVO; TRYPTOPHAN CATABOLISM; IMMUNE-SYSTEM;

D O I：

10.4049/jimmunol.1001157

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The presence in cancer tissue of Ag-specific, activated tumor infiltrating CD8(+) T cells proves that tumors express Ags capable of eliciting immune response. Therefore, in general, tumor escape from immune-mediated clearance is not attributable to immunological ignorance. However, tumor-infiltrating lymphocytes are defective in effector phase function, demonstrating tumor-induced immune suppression that likely underlies tumor escape. Since exocytosis of lytic granules is dependent upon TCR-mediated signal transduction, it is a reasonable contention that tumors may induce defective signal transduction in tumor infiltrating T cells. In this review, we consider the biochemical basis for antitumor T cell dysfunction, focusing on the role of inhibitory signaling receptors in restricting TCR-mediated signaling in tumor-infiltrating lymphocytes. The Journal of Immunology, 2010, 185: 7133-7140.

引用

页码：7133 / 7140

页数：8

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