Synthesis of a conformationally restricted analogue of paclitaxel

被引：12

作者：

Barboni, L

Lambertucci, C

Ballini, R

Appendino, G

Bombardelli, E

机构：

[1] Dipartimento Sci Chim, I-62032 Camerino, MC, Italy

[2] Dipartimento Sci & Tecnol Farmaco, I-10125 Turin, Italy

[3] Indena SPA, I-20141 Milan, Italy

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 39期

关键词：

D O I：

10.1016/S0040-4039(98)01537-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A conformationally constrained analogue of the paclitaxel side-chain was synthesised in an enantioselective way from ethyl 1H-indene-2-carboxylate. Coupling with 7-triethylsilylbaccatin III and deprotection afforded 2',2 "-methylenepaclitaxel, a novel analogue of the natural product retaining anticancer activity. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：7177 / 7180

页数：4

共 26 条

[1]

APPENDINO G, 1995, CHEM PHARM TAXOL REL, P92

[2]

BARBONI L, 1995, LIEBIGS ANN, P345

[3] EPOXIDATION WITH DIOXIRANES DERIVED FROM 2-FLUORO-2-SUBSTITUTED-1-TETRALONES AND 2-FLUORO-2-SUBSTITUTED-1-INDANONES [J].