Virulence determinants of pandemic influenza viruses

被引：234

作者：

Tscherne, Donna M. ^{[1
]}

Garcia-Sastre, Adolfo ^{[1
,2
,3
]}

机构：

[1] Mt Sinai Sch Med, Dept Microbiol, New York, NY 10029 USA

[2] Mt Sinai Sch Med, Dept Med, Div Infect Dis, New York, NY 10029 USA

[3] Mt Sinai Sch Med, Global Hlth & Emerging Pathogens Inst, New York, NY 10029 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2011年 / 121卷 / 01期

关键词：

A H1N1 VIRUS; AMINO-ACID SUBSTITUTION; TO-HUMAN TRANSMISSION; H5N1; VIRUS; RECEPTOR SPECIFICITY; IN-VITRO; MOLECULAR-BASIS; NS1; PROTEIN; AVIAN-LIKE; HEMAGGLUTININ;

D O I：

10.1172/JCI44947

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

Influenza A viruses cause recurrent, seasonal epidemics and occasional global pandemics with devastating levels of morbidity and mortality The ability of influenza A viruses to adapt to various hosts and undergo reassortment events ensures constant generation of new strains with unpredictable degrees of pathogenicity, transmissibility, and pandemic potential Currently, the combination of factors that drives the emergence of pandemic influenza is unclear, making it impossible to foresee the details of a future outbreak Identification and characterization of influenza A virus virulence determinants may provide insight into genotypic signatures of pathogenicity as well as a more thorough understanding of the factors that give rise to pandemics

引用

页码：6 / 13

页数：8

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