Long-term evolution of gut inflammation in patients with spondyloarthropathy

被引:180
作者
DeVos, M
Mielants, H
Cuvelier, C
Elewaut, A
Veys, E
机构
[1] STATE UNIV GHENT HOSP, DEPT RHEUMATOL, B-9000 GHENT, BELGIUM
[2] STATE UNIV GHENT HOSP, DEPT PATHOL, B-9000 GHENT, BELGIUM
关键词
D O I
10.1053/gast.1996.v110.pm8964393
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background & Aims: Intestinal inflammation has been observed in patients with spondyloarthropathy (SpA). This prospective study reports the evolution of the intestinal inflammation observed in patients with SpA. Methods: One hundred twenty-three patients with SpA who had undergone initial endoscopy were clinically reassessed, intestinal evolution was evaluated by ileocolonoscopy and the histological study of biopsy specimens in 49 patients, Results Articular remission rates were independent of initial gut inflammation and associated with endoscopic and histological remission, Persistent gut inflammation was observed in active joint disease, Gut inflammation rarely disappeared, despite the persistence of articular complaints. Initial chronic gut inflammation implied a high risk of evolution to ankylosing spondylitis, Evolution to inflammatory bowel disease (IBD) was observed in 7% of patients. Mainly patients with initial:chronic inflammation and mild complaints of diarrhea were It risk, Sulfasalazine was more frequently needed in the treatment of patients with gut inflammation with a beneficial effect on articular and intestinal evolution but did not prevent evolution to IBD. Conclusions: This study supports the etiopathogenetic role of the gut in SpA, Presence of chronic gut inflammation and mild complaints of diarrhea implies a high risk of evolution to ankylosing spondylitis and BED. Sulfasalazine has a beneficial effect on articular activity by controlling gut inflammation, but it cannot prevent evolution to overt IBD.
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收藏
页码:1696 / 1703
页数:8
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