Nuclear factor-κB, an unappreciated tumor suppressor

被引：61

作者：

Chen, Fei ^{[1
]}

Castranova, Vince ^{[1
]}

机构：

[1] Natl Inst Occupat Safety & Hlth, Hlth Effects Lab, Morgantown, WV 26505 USA

来源：

CANCER RESEARCH | 2007年 / 67卷 / 23期

关键词：

D O I：

10.1158/0008-5472.CAN-07-1576

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The notion that nuclear factor-kappa B (NF-kappa B) is a tumor-promoting transcription factor has become a widely accepted dogma in biology. However, recent findings suggest an inhibitory role for NF-kappa B in carcinogenesis and tumorigenesis. Although the tumor suppressor-like effect of NF-kappa B remains to be rigorously established by further studies using cellular and animal models, these latest findings warrant caution with respect to blockage of NF-kappa B activation as a broad strategy in treating cancers.

引用

页码：11093 / 11098

页数：6

共 20 条

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