Involvement of the suprachiasmatic nucleus in diurnal ACTH and corticosterone responsiveness to stress

被引：53

作者：

Sage, D ^{[1
]}

Maurel, D ^{[1
]}

Bosler, O ^{[1
]}

机构：

[1] Univ Mediterranee, Fac Med Nord, IFR Jean Roche, INSERM,U501, F-13916 Marseille 20, France

来源：

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM | 2001年 / 280卷 / 02期

关键词：

restraint stress; hypothalamic-pituitary-adrenal axis; neuroendocrine responses to stress; circadian rhythm;

D O I：

10.1152/ajpendo.2001.280.2.E260

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We explored the contribution of the suprachiasmatic nucleus (SCN) in ACTH and corticosterone (CORT) diurnal responsiveness of the rat to restraint stress applied either in the morning (AM) or in the evening (PM). Ablation of the SCN caused the diurnal rhythmicity of the CORT response to disappear but had no effects on AM vs. PM differences in the ACTH response. Stress-response curves in SCN-lesioned rats that had prestress levels of CORT either in the AM range or in the PM range, when compared with those obtained for AM and PM controls, showed that the SCN differentially regulates the stress response depending on the underlying secretory activity of the adrenal cortex. When basal CORT secretion is at its lowest, the SCN inhibits CORT responsiveness to stress by controlling pituitary corticotrophs; but when it is at its highest, it has a permissive action that will bypass the hypophysis and reach the adrenals to adjust the response of the gland to ACTH.

引用

页码：E260 / E269

页数：10

共 32 条

[1] EFFECTS OF DESTRUCTION OF THE SUPRACHIASMATIC NUCLEI ON THE CIRCADIAN-RHYTHMS IN PLASMA-CORTICOSTERONE, BODY-TEMPERATURE, FEEDING AND PLASMA THYROTROPIN [J].

ABE, K ;

KRONING, J ;

GREER, MA ;

CRITCHLOW, V .

NEUROENDOCRINOLOGY, 1979, 29 (02) :119-131

[2] FEEDBACK SENSITIVITY OF THE RAT HYPOTHALAMO-PITUITARY-ADRENAL AXIS AND ITS CAPACITY TO ADJUST TO EXOGENOUS CORTICOSTERONE [J].

AKANA, SF ;

SCRIBNER, KA ;

BRADBURY, MJ ;

STRACK, AM ;

WALKER, CD ;

DALLMAN, MF .

ENDOCRINOLOGY, 1992, 131 (02) :585-594

[3] REGULATION OF ACTIVITY IN THE HYPOTHALAMO-PITUITARY-ADRENAL AXIS IS INTEGRAL TO A LARGER HYPOTHALAMIC SYSTEM THAT DETERMINES CALORIC FLOW [J].

AKANA, SF ;

STRACK, AM ;

HANSON, ES ;

DALLMAN, MF .

ENDOCRINOLOGY, 1994, 135 (03) :1125-1134

[4] RESET OF FEEDBACK IN THE ADRENOCORTICAL SYSTEM - AN APPARENT SHIFT IN SENSITIVITY OF ADRENOCORTICOTROPIN TO INHIBITION BY CORTICOSTERONE BETWEEN MORNING AND EVENING [J].

AKANA, SF ;

CASCIO, CS ;

DU, JZ ;

LEVIN, N ;

DALLMAN, MF .

ENDOCRINOLOGY, 1986, 119 (05) :2325-2332

[5] STRESS-INDUCED ADRENOCORTICOTROPIN SECRETION - DIURNAL RESPONSES AND DECREASES DURING STRESS IN THE EVENING ARE NOT DEPENDENT ON CORTICOSTERONE [J].

BRADBURY, MJ ;

CASCIO, CS ;

SCRIBNER, KA ;

DALLMAN, MF .

ENDOCRINOLOGY, 1991, 128 (02) :680-688

[6] SUPRACHIASMATIC NUCLEUS LESION INCREASES CORTICOSTERONE SECRETION [J].

BUIJS, RM ;

KALSBEEK, A ;

VANDERWOUDE, TP ;

VANHEERIKHUIZE, JJ ;

SHINN, S .

AMERICAN JOURNAL OF PHYSIOLOGY, 1993, 264 (06) :R1186-R1192

[7] Anatomical and functional demonstration of a multisynaptic suprachiasmatic nucleus adrenal (cortex) pathway [J].

Buijs, RM ;

Wortel, J ;

van Heerikhuize, JJ ;

Feenstra, MGP ;

Ter Horst, GJ ;

Romijn, HJ ;

Kalsbeek, A .

EUROPEAN JOURNAL OF NEUROSCIENCE, 1999, 11 (05) :1535-1544

[8] Novel environment induced inhibition of corticosterone secretion: Physiological evidence for a suprachiasmatic nucleus mediated neuronal hypothalamo-adrenal cortex pathway [J].

Buijs, RM ;

Wortel, J ;

VanHeerikhuize, JJ ;

Kalsbeek, A .

BRAIN RESEARCH, 1997, 758 (1-2) :229-236

[9] ADRENOCORTICOTROPIN, BETA-ENDORPHIN, AND CORTICOSTERONE SECRETION IN BRATTLEBORO RATS [J].

CONTEDEVOLX, B ;

OLIVER, C ;

GIRAUD, P ;

CASTANAS, E ;

BOUDOURESQUE, F ;

GILLIOZ, P ;

MILLET, Y .

ENDOCRINOLOGY, 1982, 110 (06) :2097-2100

[10]

DALLMAN MF, 1978, AM J PHYSIOL, V235, P210

← 1 2 3 4 →