Small-conductance, Ca2+-activated K+ channel SK3 generates age-related memory and LTP deficits

被引：97

作者：

Blank, T ^{[1
]}

Nijholt, I ^{[1
]}

Kye, MJ ^{[1
]}

Radulovic, J ^{[1
]}

Spiess, J ^{[1
]}

机构：

[1] Max Planck Inst Expt Med, Dept Mol Neuroendocrinol, D-37075 Gottingen, Germany

来源：

NATURE NEUROSCIENCE | 2003年 / 6卷 / 09期

关键词：

D O I：

10.1038/nn1101

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Cognitive deficits are among the most devastating changes associated with the aging process. Age-related decrement in performance on learning tasks(1,2) is correlated with substantial changes in neuronal signal processing in the hippocampus(3-5). Here we show that elevated expression of small-conductance Ca2+-activated K+ channels (SK channels) of the SK3 type in hippocampi of aged mice contributes to reduced long-term potentiation (LTP) and impaired trace fear conditioning, a hippocampus-dependent learning task(6,7).

引用

页码：911 / 912

页数：2

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