Psychosocial factors and cardiovascular diseases

被引:527
作者
Everson-Rose, SA [1 ]
Lewis, TT
机构
[1] Rush Univ, Ctr Med, Dept Prevent Med, Chicago, IL 60612 USA
[2] Rush Univ, Ctr Med, Dept Psychol, Chicago, IL 60612 USA
[3] Rush Univ, Ctr Med, Rush Inst Healthy Aging, Chicago, IL 60612 USA
关键词
depression; anger; hostility; stress; pathophysiological mechanisms;
D O I
10.1146/annurev.publhealth.26.021304.144542
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Rapidly accruing evidence from a diversity of disciplines supports the hypothesis that psychosocial factors are related to morbidity and mortality due to cardiovascular diseases. We review relevant literature on (a) negative emotional states, including depression, anger and hostility, and anxiety; (b) chronic and acute psychosocial stressors; and (c) social ties, social support, and social conflict. All three of these psychosocial domains have been significantly associated with increased risk of cardiovascular morbidity and mortality. We also discuss critical pathophysiological mechanisms and pathways that likely operate in a synergistic and integrative way to promote atherogenesis and related clinical manifestations. We conclude by discussing some of the important challenges and opportunities for future investigations.
引用
收藏
页码:469 / 500
页数:32
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