Polymorphisms of vitamin D receptor gene in Turkish familial psoriasis patients

被引:53
作者
Dayangac-Erden, Didem [1 ]
Karaduman, Aysen
Erdem-Yurter, Hayat
机构
[1] Hacettepe Univ, Fac Med, Dept Med Biol, TR-06100 Ankara, Turkey
[2] Hacettepe Univ, Fac Med, Dept Dermatol, TR-06100 Ankara, Turkey
关键词
vitamin D receptor gene polymorphism; calcipotriol; psoriasis; BONE-MINERAL DENSITY; CALCIPOTRIOL;
D O I
10.1007/s00403-007-0782-5
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Psoriasis is characterized by hyperproliferation and abnormal differentiation of keratinocytes, and inflammation. 1,25-Dihydroxyvitamin D3, which is used for the treatment of psoriasis, binds to vitamin D receptor (VDR) and modulates gene transcription. We analyzed VDR gene FokI, ApaI and TaqI polymorphisms in 51 Turkish familial psoriasis patients (psoriasis vulgaris and psoriatic arthritis) and 100 healthy subjects, and evaluated the correlation between VDR genotypes and calcipotriol response. We found that the TT genotype was significantly more frequent in the patients than in the controls (51 vs. 35%: P <= 0.05). The frequency of the T allele in patients was also significantly higher than that in the controls (73.5 vs. 59.5%: P <= 0.025). In psoriatic arthritis patients, T allele frequency was even higher (91.7%: P <= 0.05). With regard to response to calcipotriol treatment, in nonresponsive patients TT genotype and T allele frequencies were higher than they were in the controls (63.6 vs. 35%: P <= 0.025, 81.8 vs. 59.5%: P <= 0.01, respectively). In conclusion, we show that VDR gene TaqI polymorphism is associated with familial psoriasis in the Turkish population. We also demonstrate that VDR gene polymorphisms may play a role in partial resistance to calcipotriol therapy.
引用
收藏
页码:487 / 491
页数:5
相关论文
共 21 条
[1]   Genetic determinants of bone mass [J].
Audí, L ;
García-Ramírez, M ;
Carrascosa, A .
HORMONE RESEARCH, 1999, 51 (03) :105-123
[2]  
DeLuca HF, 1998, NUTR REV, V56, pS4
[3]   Does the determination of the Bb vitamin D receptor genotype identify psoriasis vulgaris patients responsive to topical tacalcitol? [J].
Giomi, B ;
Ruggiero, M ;
Fabbri, P ;
Gulisano, M ;
Peruzzi, B ;
Caproni, M ;
Pacini, S .
JOURNAL OF DERMATOLOGICAL SCIENCE, 2005, 37 (03) :180-181
[4]   Vitamin D receptor gene polymorphisms, particularly the novel A-1012G promoter polymorphism, are associated with vitamin D3 responsiveness and non-familial susceptibility in psoriasis [J].
Halsall, JA ;
Osborne, JE ;
Pringle, JH ;
Hutchinson, PE .
PHARMACOGENETICS AND GENOMICS, 2005, 15 (05) :349-355
[5]   The vitamin D receptor start codon polymorphism (FokI) and bone mineral density in premenopausal American black and white women [J].
Harris, SS ;
Eccleshall, TR ;
Gross, C ;
DawsonHughes, B ;
Feldman, D .
JOURNAL OF BONE AND MINERAL RESEARCH, 1997, 12 (07) :1043-1048
[6]   Association between vitamin D receptor gene polymorphism and psoriasis among the Turkish population [J].
Kaya, TI ;
Erdal, ME ;
Tursen, U ;
Camdeviren, H ;
Gunduz, O ;
Soylemez, F ;
Ikizoglu, G .
ARCHIVES OF DERMATOLOGICAL RESEARCH, 2002, 294 (06) :286-289
[7]   Vitamin D receptor polymorphism and treatment of psoriasis with calcipotriol [J].
Kontula, K ;
Valimaki, S ;
Kainulainen, K ;
Viitanen, AM ;
KeskiOja, J .
BRITISH JOURNAL OF DERMATOLOGY, 1997, 136 (06) :977-978
[8]   DOUBLE-BLIND, RIGHT LEFT COMPARISON OF CALCIPOTRIOL AND BETAMETHASONE VALERATE IN TREATMENT OF PSORIASIS-VULGARIS [J].
KRAGBALLE, K ;
GJERTSEN, BT ;
DEHOOP, D ;
KARLSMARK, T ;
VANDEKERKHOF, PCM ;
LARKO, O ;
NIEBOER, C ;
ROEDPETERSEN, J ;
STRAND, A ;
TIKJOB, G .
LANCET, 1991, 337 (8735) :193-196
[9]   PSORIASIS [J].
KRUEGER, GG ;
BERGSTRESSER, PR ;
LOWE, NJ ;
VOORHEES, JJ ;
WEINSTEIN, GD .
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 1984, 11 (05) :937-947
[10]   Vitamin D receptor genotypes are not associated with clinical response to calcipotriol in Korean psoriasis patients [J].
Lee, DY ;
Park, BS ;
Choi, KH ;
Jeon, JH ;
Cho, KH ;
Song, KY ;
Kim, IG ;
Youn, JI .
ARCHIVES OF DERMATOLOGICAL RESEARCH, 2002, 294 (1-2) :1-5