The emergence of ADAM10 as a regulator of lymphocyte development and autoimmunity

被引：28

作者：

Gibb, David R. ^{[1
]}

Saleem, Sheinei J. ^{[1
]}

Chaimowitz, Natalia S. ^{[1
]}

Mathews, Joel ^{[1
]}

Conrad, Daniel H. ^{[1
]}

机构：

[1] Virginia Commonwealth Univ, Dept Microbiol & Immunol, Sch Med, Richmond, VA 23298 USA

来源：

MOLECULAR IMMUNOLOGY | 2011年 / 48卷 / 11期

关键词：

A disintegrin and metalloproteinase 10; Notch; CD23; Kuzbanian; Lymphocyte development; Autoimmunity; NECROSIS-FACTOR-ALPHA; COLLAGEN-INDUCED ARTHRITIS; ACUTE LYMPHOBLASTIC-LEUKEMIA; AMYLOID PRECURSOR PROTEIN; CONVERTING ENZYME ADAM17; CELL-SURFACE EXPRESSION; EPIDERMAL-GROWTH-FACTOR; ZONE B-CELLS; GAMMA-SECRETASE; NOTCH LIGAND;

D O I：

10.1016/j.molimm.2010.12.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Proteolytic processing of transmembrane receptors and ligands can have a dramatic impact on cell signaling processes and subsequent cellular responses, including activation and differentiation. A member of the disintegrin and metalloproteinase family, ADAM10, has emerged as a prominent regulator of numerous receptors and ligands, including Notch and CD23. Here, we review studies resulting from the recent generation of ADAM10 conditional knockout mice which revealed a critical role for ADAM10 in Notch-dependent lymphocyte development. Additionally, we discuss results of numerous in vitro and ex vivo studies indicating that ADAM10 regulates the production of multiple secreted factors that contribute to autoimmune reactions. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：1319 / 1327

页数：9

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