Modulation of agonist and antagonist interactions in serotonin 1A receptors by alcohols

被引：24

作者：

Harikumar, KG ^{[1
]}

Chattopadhyay, A ^{[1
]}

机构：

[1] Ctr Cellular & Mol Biol, Hyderabad 500007, Andhra Pradesh, India

来源：

FEBS LETTERS | 1998年 / 438卷 / 1-2期

关键词：

alcohol; serotonin 1A receptor; 8-hydroxy-2-(di-N-propylamino)tetralin; 4-(2 '-methoxy)-phenyl-1-[2 '-(N-2 ''-pyridinyl)-p-iodobenzamido]ethyl-piperazine; 4-(2 '-methoxy)-phenyl-1-[2 '-(N-2 ''-pyridinyl)-p-fluorobenzamido]ethyl-piperazine; bovine hippocampus;

D O I：

10.1016/S0014-5793(98)01284-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The scrotonin type 1A (5-HT1A) receptors are members of a superfamily of seven transmembrane domain receptors that couple to GTP binding regulatory proteins (G-proteins), Serotonergic signalling has been shown to play an important role in alcohol tolerance and dependence, We have studied the effects of alcohols on ligand (agonist and antagonist) binding to bovine hippocampal 5-HT1A receptor in native as well as solubilized membranes. Our results show that alcohols inhibit the specific binding of the agonist OH-DPAT and the antagonist p-MPPF to 5-HT1A receptors in a concentration-dependent manner. (C) 1998 Federation of European Biochemical Societies.

引用

页码：96 / 100

页数：5

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