Synthesis of 3-arylpiperidines by a radical 1,4-aryl migration

被引：54

作者：

Gheorghe, A ^{[1
]}

Quiclet-Sire, N ^{[1
]}

Vila, X ^{[1
]}

Zard, SZ ^{[1
]}

机构：

[1] Ecole Polytech, Dept Chim, Organ Synth Lab, F-91128 Palaiseau, France

来源：

ORGANIC LETTERS | 2005年 / 7卷 / 08期

关键词：

D O I：

10.1021/ol0503642

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A route to 3-arylpiperidines, 3-arylpyridines, and 5-arylpiperidin-2-ones involving a radical 1,4-aryl migration has been explored. The sequence requires a xanthate addition to an *allylarylsulfonamide, followed by acetylation and treatment with dilauroyl peroxide to give the 1,4-aryl transfer product, which upon acidic hydrolysis affords the desired piperidine derivative.

引用

页码：1653 / 1656

页数：4

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