Dioscorealides and dioscoreanone, novel cytotoxic naphthofuranoxepins, and 1,4-phenanthraquinone from Dioscorea membranacea Pierre

被引：33

作者：

Itharat, A

Plubrukarn, A

Kongsaeree, P

Bui, T

Keawpradub, N

Houghton, PJ ^{[1
]}

机构：

[1] Prince Songkla Univ, Fac Pharmaceut Sci, Dept Pharmacognosy & Pharmaceut Botany, Songkhla 90112, Thailand

[2] Mahidol Univ, Fac Sci, Dept Chem, Bangkok 10400, Thailand

[3] Kings Coll London, Dept Pharm, Pharmacognosy Res Labs, London SE1 8WA, England

来源：

ORGANIC LETTERS | 2003年 / 5卷 / 16期

关键词：

D O I：

10.1021/ol034926y

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学]; 081704 [应用化学];

摘要：

graphics Commonly used among ingredients in Thai traditional anticancer preparations, the rhizome of Dioscorea membranacea Pierre was found potently cytotoxic and possibly contributed to such a therapeutic effect. Bioassay-guided isolation resulted in two novel cytotoxic naphthofuranoxepins, dioscorealides A (1) and B (2), and a new 1,4-phenanthraquinone, dioscoreanone (3). The structure determination, achieved mainly by means of NMR and CD spectral and X-ray crystallographic analyses, and cytotoxicity are discussed here.

引用

页码：2879 / 2882

页数：4

共 3 条

[1]

Boonyaratanakornkit L, 1993, THAI J PHARM SCI, V1, P79

[2]

In vitro keratinocyte antiproliferant effect of Centella asiatica extract and triterpenoid saponins [J].