Oxidative stress and chronic inflammation in osteoarthritis: can NRF2 counteract these partners in crime?

被引：259

作者：

Marchev, Andrey S. ^{[1
]}

Dimitrova, Petya A. ^{[2
]}

Burns, Andrew J. ^{[3
]}

Kostov, Rumen V. ^{[3
]}

Dinkova-Kostova, Albena T. ^{[3
,4
,5
]}

Georgiev, Milen I. ^{[1
]}

机构：

[1] Bulgarian Acad Sci, Stephan Angeloff Inst Microbiol, Grp Plant Cell Biotechnol & Metabol, 139 Ruski Blvd, Plovdiv 4000, Bulgaria

[2] Bulgarian Acad Sci, Stephan Angeloff Inst Microbiol, Dept Immunol, Sofia, Bulgaria

[3] Univ Dundee, Sch Med, Jacqui Wood Canc Ctr, Div Canc Res, Dundee, Scotland

[4] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA

[5] Johns Hopkins Univ, Sch Med, Dept Pharmacol & Mol Sci, Baltimore, MD 21205 USA

来源：

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES | 2017年 / 1401卷 / 01期

基金：

英国生物技术与生命科学研究理事会;

关键词：

osteoarthritis; NRF2; ROS; inflammation; phytochemicals; TRANSCRIPTION FACTOR NRF2; DOWN-REGULATION; XANTHINE OXIDOREDUCTASE; SIGNALING PATHWAYS; GENE-EXPRESSION; MITOCHONDRIAL DYSFUNCTION; CHEMOPREVENTIVE AGENTS; RHEUMATOID-ARTHRITIS; SYNOVIAL-FLUID; NITRIC-OXIDE;

D O I：

10.1111/nyas.13407

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

Osteoarthritis (OA) is an age-related joint degenerative disease associated with pain, joint deformity, and disability. The disease starts with cartilage damage but then progressively involves subchondral bone, causing an imbalance between osteoclast-driven bone resorption and osteoblast-driven remodeling. Here, we summarize the data for the role of oxidative stress and inflammation in OA pathology and discuss how these two processes are integrated during OA progression, as well as their contribution to abnormalities in cartilage/bone metabolism and integrity. At the cellular level, oxidative stress and inflammation are counteracted by transcription factor nuclear factor erythroid p45-related factor 2 (NRF2), and we describe the regulation of NRF2, highlighting its role in OA pathology. We also discuss the beneficial effect of some phytonutrients, including the therapeutic potential of NRF2 activation, in OA.

引用

页码：114 / 135

页数：22

共 192 条

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