NO synthesis inhibition decreases cortical ACh release and impairs retention of a conditioned response

被引：41

作者：

Kopf, SR

Benton, RS

Kalfin, R

Giovannini, MG

Pepeu, G ^{[1
]}

机构：

[1] Univ Florence, Dept Preclin & Clin Pharmacol, Viale Pieraccini 6, I-50139 Florence, Italy

[2] IDEA AG, Munchner Technol Zentrum, D-80087 Munich, Germany

[3] Arizona Res Labs, Div Neural Syst Memory & Aging, Tucson, AZ 85724 USA

[4] Bulgarian Acad Sci, Inst Physiol, BU-1113 Sofia, Bulgaria

来源：

BRAIN RESEARCH | 2001年 / 894卷 / 01期

关键词：

acetylcholine; memory; microdialysis; nitric oxide; passive avoidance;

D O I：

10.1016/S0006-8993(00)03148-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We investigated in rats the effect N-G-nitro-(L)-arginine methyl ester ((L)-NAME) on retention of a passive avoidance response, and cortical ACh release monitored using the microdialysis technique. Post-training administration of (L)-NAME impaired 24 h retention of a passive avoidance and decreased cortical ACh release. Both effects of (L)-NAME were reversed by (L)-Arg. These results suggest that nitric oxide is involved in retention of the passive avoidance response through the modulation of the forebrain cholinergic system. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

收藏

页码：141 / 144

页数：4

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