Comparative study on the vasodilatory effects of three quinazoline alkaloids isolated from Evodia rutaecarpa

被引：125

作者：

Chiou, WF

Liao, JF

Chen, CF

机构：

[1] NATL RES INST CHINESE MED, TAIPEI HSIEN, TAIWAN

[2] NATL YANG MING UNIV, DEPT PHARMACOL, TAIPEI, TAIWAN

[3] NATL YANG MING UNIV, INST PHARMACOL, TAIPEI, TAIWAN

来源：

JOURNAL OF NATURAL PRODUCTS | 1996年 / 59卷 / 04期

关键词：

D O I：

10.1021/np960161+

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

The vasoreactivity of dehydroevodiamine (1), evodiamine (2), and rutaecarpine (3), quinazoline alkaloids isolated from Evodia rutaecarpa, to aorta smooth muscle demonstrated that they produce a vasodilatory effect on endothelium-intact rat aorta with equal potency. Compound 3 produced a full (100%) nitric oxide-dependent vasodilatation, whereas 2 and 1 produced a partially endothelium-dependent effect, 50% and 10%, respectively. At the same time, 1 and 2 may also act by other mechanisms, including probably an al-adrenoceptor blocking action and a 5-HT antagonizing action, respectively.

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页码：374 / 378

页数：5

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