Cerebral uric acid increases following experimental traumatic brain injury in rat

被引：33

作者：

Tayag, EC

Nair, SN

Wahhab, S

Katsetos, CD

Lighthall, JW

Lehmann, JC

机构：

[1] MED COLL PENN & HAHNEMANN UNIV, DEPT NEUROSURG, PHILADELPHIA, PA 19102 USA

[2] MED COLL PENN & HAHNEMANN UNIV, DEPT PATHOL, PHILADELPHIA, PA 19102 USA

[3] GM CORP, RES LABS, DEPT BIOMED SCI, WARREN, MI 48090 USA

来源：

BRAIN RESEARCH | 1996年 / 733卷 / 02期

关键词：

uric acid; thalamus; cortex; rat; traumatic brain injury; microdialysis;

D O I：

10.1016/0006-8993(96)00669-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Following traumatic brain injury (TBI), cortical and thalamic areas were analyzed histologically and by high-performance liquid chromatography with electrochemical detection for uric acid at various survival times. Following TBI, cortical uric acid was elevated by ten-fold at 24 and 48 h, but not at 1 h post-TBI. Histological evidence of neurodegeneration was found not only in cortex but also in the anteroventral thalamus. These data suggest that as in stroke, uric acid measurements may be a convenient and sensitive method for measuring peroxidative status in TBI.

引用

收藏

页码：287 / 291

页数：5

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