A favorable response to antiparkinsonian treatment in juvenile neuronal ceroid lipofuscinosis

被引：21

作者：

Åberg, LE

Rinne, JO

Rajantie, I

Santavuori, P

机构：

[1] Univ Helsinki, Hosp Children & Adolescents, Dept Pediat, Helsinki 00029, Finland

[2] Univ Helsinki, Hosp Children & Adolescents, Dept Neurol, Helsinki 00029, Finland

[3] Univ Turku, Dept Neurol, FIN-20520 Turku, Finland

[4] Univ Turku, Turku PET Ctr, FIN-20520 Turku, Finland

来源：

NEUROLOGY | 2001年 / 56卷 / 09期

关键词：

D O I：

10.1212/WNL.56.9.1236

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

To study the effect of dopaminergic drugs on the parkinsonism in juvenile neuronal ceroid lipofuscinosis, the authors conducted an open study of 21 patients. According to the motor Unified PD Rating Scale (UPDRS) score, treatment was initiated with either levodopa (n = 10) or selegiline (n = 6). Five patients served as a control group. The UPDRS score after 1 year was compared with the score at onset. Both in the control group and in the selegiline group, the mean UPDRS score increased, whereas in the levodopa group, the mean UPDRS score decreased. The difference between the levodopa group and the control group was significant.

引用

页码：1236 / 1239

页数：4

共 10 条

[1] Decreased striatal dopamine transporter density in JNCL patients with parkinsonian symptoms [J].