Infectivity of Cryptosporidium hominis and Cryptosporidium parvum genotype 2 isolates in immunosuppressed Mongolian gerbils

被引：29

作者：

Baishanbo, A

Gargala, G

Delaunay, A

François, A

Ballet, JJ ^{[1
]}

Favennec, L

机构：

[1] CHU Clemenceau, Lab Immunol & Immunopathol, UPRES EA 2128, F-14033 Caen, France

[2] CHU Charles Nicolle, Parasitol Lab, Rouen, France

[3] CHU Charles Nicolle, ADEN EA 3234, Rouen, France

[4] CHU Charles Nicolle, Lab Histopathol, Rouen, France

来源：

INFECTION AND IMMUNITY | 2005年 / 73卷 / 08期

关键词：

D O I：

10.1128/IAI.73.8.5252-5255.2005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

One-month-old dexamethasone-immunosuppressed Mongolian gerbils were challenged with 1 oocyst to 2 x 10(5) oocysts from two isolates genotyped as Cryptosporidium hominis and C. parvum (genotype 2), respectively. A similar dose-dependent gut infection was obtained, and the initial genotype maintained for 21 to 22 days. The data suggest that immunosuppressed gerbils provide a reliable rodent model of persistent C. hominis infection.

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收藏

页码：5252 / 5255

页数：4

相关论文

共 42 条

[1] Rapid displacement of Cryptosporidium parvum type 1 by type 2 in mixed infections in piglets [J].

Akiyoshi, DE ;

Mor, S ;

Tzipori, S .

INFECTION AND IMMUNITY, 2003, 71 (10) :5765-5771

[2] Genetic analysis of a Cryptosporidium parvum human genotype 1 isolate passaged through different host species [J].

Akiyoshi, DE ;

Feng, X ;

Buckholt, MA ;

Widmer, G ;

Tzipori, S .

INFECTION AND IMMUNITY, 2002, 70 (10) :5670-5675

[3] Differentiation between human and animal isolates of Cryptosporidium parvum using molecular and biological markers [J].

Awad-El-Kariem, FM ;

Robinson, HA ;

Petry, F ;

McDonald, V ;

Evans, D ;

Casemore, D .

PARASITOLOGY RESEARCH, 1998, 84 (04) :297-301

[4] Comparative efficacy evaluation of dicationic carbazole compounds, nitazoxanide, and paromomycin against Cryptosporidium parvum infections in a neonatal mouse model [J].

Blagburn, BL ;

Drain, KL ;

Land, TM ;

Kinard, RG ;

Moore, PH ;

Lindsay, DS ;

Patrick, DA ;

Boykin, DW ;

Tidwell, RR .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1998, 42 (11) :2877-2882

[5] ENUMERATION OF SELECTED LEUKOCYTES IN THE SMALL-INTESTINE OF BALB/C MICE INFECTED WITH CRYPTOSPORIDIUM-PARVUM [J].

BOHER, Y ;

PEREZSCHAEL, I ;

CACERESDITTMAR, G ;

URBINA, G ;

GONZALEZ, R ;

KRAAL, G ;

TAPIA, FJ .

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1994, 50 (02) :145-151

[6] RAT MODEL FOR HUMAN CRYPTOSPORIDIOSIS [J].

BRASSEUR, P ;

LEMETEIL, D ;

BALLET, JJ .

JOURNAL OF CLINICAL MICROBIOLOGY, 1988, 26 (05) :1037-1039

[7] Cryptosporidium parvum: Intensity of infection and oocyst excretion patterns in healthy volunteers [J].

Chappell, CL ;

Okhuysen, PC ;

Sterling, CR ;

DuPont, HL .

JOURNAL OF INFECTIOUS DISEASES, 1996, 173 (01) :232-236

[8] Current concepts: Cryptosporidiosis [J].

Chen, XM ;

Keithly, JS ;

Paya, CV ;

LaRusso, NF .

NEW ENGLAND JOURNAL OF MEDICINE, 2002, 346 (22) :1723-1731

[9] CRYPTOSPORIDIOSIS [J].

CURRENT, WL ;

GARCIA, LS .

CLINICAL MICROBIOLOGY REVIEWS, 1991, 4 (03) :325-358

[10] Quantitative flow cytometric evaluation of maximal Cryptosporidium parvum oocyst infectivity in a neonate mouse model [J].

Delaunay, A ;

Gargala, G ;

Li, XD ;

Favennec, L ;

Ballet, JJ .

APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2000, 66 (10) :4315-4317

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