Alteration of Th17 and Treg cell subpopulations co-exist in patients affected with systemic sclerosis

被引：134

作者：

Fenoglio, Daniela ^{[1
,2
]}

Battaglia, Florinda ^{[2
]}

Parodi, Alessia ^{[2
]}

Stringara, Silvia ^{[2
]}

Negrini, Simone ^{[1
,2
]}

Panico, Nicoletta ^{[1
]}

Rizzi, Marta ^{[2
]}

Kalli, Francesca ^{[2
]}

Conteduca, Giuseppina ^{[2
]}

Ghio, Massimo ^{[1
]}

De Palma, Raffaele ^{[3
]}

Indiveri, Francesco ^{[1
,2
]}

Filaci, Gilberto ^{[1
,2
]}

机构：

[1] Univ Genoa, Dept Internal Med DIMI, I-16132 Genoa, Italy

[2] Univ Genoa, CEBR, I-16132 Genoa, Italy

[3] Univ Naples 2, Dept Clin & Expt Med, Policlin 2, Naples, Italy

来源：

CLINICAL IMMUNOLOGY | 2011年 / 139卷 / 03期

关键词：

Systemic sclerosis; Th17; cells; Treg; REGULATORY T-CELLS; TGF-BETA; SUPPRESSOR LYMPHOCYTES; PERIPHERAL-BLOOD; DISEASE; INTERLEUKIN-17; PATHOGENESIS; PHENOTYPE; T(H)17; IL-17;

D O I：

10.1016/j.clim.2011.01.013

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Aim of the study has been to understand the relationship between TH17 and Treg cell subsets in patients affected with systemic sclerosis (SSc). Phenotypes and functions of Th17 and Treg cell subsets were analyzed in a series of 36 SSc patients. Th17 cell concentration in the peripheral blood was found to be increased in SSc patients with respect to healthy controls independently from type or stage of disease. After PBMC stimulation with a polyclonal stimulus or Candida albicans antigens the frequency of Th17 T cell clones was significantly higher in SSc patients with respect to controls suggesting the skewing of immune response in SSc patients toward Th17 cell generation/expansion. Concerning the Treg compartment, both CD4+CD25+ and CD8+CD28- Treg subsets showed quantitative and qualitative alteration in the peripheral blood of SSc patients. Collectively, these data highlight the existence of an imbalanced ratio between Th17 and Treg cell subsets in SSc patients. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：249 / 257

页数：9

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