Advancing the field of drug delivery: Taking aim at cancer

被引：257

作者：

Moses, MA

Brem, H

Langer, R

机构：

[1] MIT, Dept Chem Engn, Cambridge, MA 02139 USA

[2] Childrens Hosp, Vasc Biol Program, Boston, MA 02115 USA

[3] Childrens Hosp, Dept Surg, Boston, MA 02115 USA

[4] Harvard Univ, Sch Med, Boston, MA 02115 USA

[5] Johns Hopkins Univ, Sch Med, Dept Neurosurg, Baltimore, MD 21205 USA

来源：

CANCER CELL | 2003年 / 4卷 / 05期

关键词：

D O I：

10.1016/S1535-6108(03)00276-9

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Drug delivery systems for cancer therapeutics have now been used by millions of patients and have resulted in the creation of new therapies as well as significantly improving existing ones. Here we discuss a number of the drug delivery systems that have been approved by regulatory authorities and that are currently in clinical use, such as controlled delivery of cancer therapeutics, local chemotherapy, polymer drug conjugates, liposomal systems, and transdermal drug delivery patches. The next generation of "smart" drug delivery approaches such as controlled release microchips are discussed as are some of the future challenges and directions in this field.

引用

页码：337 / 341

页数：5

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