Odorant concentration and receptor potential in olfactory sensory neurons

The first step of olfactory transduction consists of the interaction of odorant molecules with receptor proteins. This interaction can be described either as a single-step reaction (binding only) or as a double-step one (binding and activation). The number of bound or activated receptors is analyzed as a function of the external concentration of odorant molecules in two models of the neuron environment. In one model the odorant molecules can freely access and leave the vicinity of receptors, whereas in the other a real perireceptor space, partly isolated from the external environment is considered. The steady state and time variable responses to the stimulus are investigated. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.