Characterization of a humanized monoclonal antibody recognizing clumping factor a expressed by Staphylococcus aureus

被引：57

作者：

Domanski, PJ

Patel, PR

Bayer, AS

Zhang, L

Hall, AE

Syribeys, PJ

Gorovits, EL

Bryant, D

Vernachio, JH

Hutchins, JT

Patti, JM

机构：

[1] Inhibitex Inc, Alpharetta, GA 30004 USA

[2] LA Biomed Res, Torrance, CA USA

来源：

INFECTION AND IMMUNITY | 2005年 / 73卷 / 08期

关键词：

D O I：

10.1128/IAI.73.8.5229-5232.2005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We report the humanization and characterization of monoclonal antibody (MAb) T1-2 or tefibazumab, a monoclonal antibody that recognizes clumping factor A expressed on the surface of Staphylococcus aureus. We demonstrate that the binding kinetics of MAb T1-2 is indistinguishable compared to that of its murine parent. Furthermore, MAb T1-2 is shown to enhance the opsonophagocytic uptake of ClfA-coated latex beads, protect against an intravenous challenge in a prophylactic model of rabbit infective endocarditis, and enhance the efficacy of vancomycin therapy in a therapeutic model of established infective endocarditis.

引用

收藏

页码：5229 / 5232

页数：4

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