Tissue distribution of dextran sulfate sodium (DSS) in the acute phase of murine DSS-induced colitis

被引：81

作者：

Kitajima, S ^{[1
]}

Takuma, S ^{[1
]}

Morimoto, M ^{[1
]}

机构：

[1] Saga Med Sch, Ctr Lab Anim, Saga 8498501, Japan

来源：

JOURNAL OF VETERINARY MEDICAL SCIENCE | 1999年 / 61卷 / 01期

关键词：

colitis; dextran sulfate sodium; distribution;

D O I：

10.1292/jvms.61.67

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

In the present study, we examined histochemically the tissue distribution of dextran sulfate sodium (DSS) in the acute phase of murine colitis induced by administering DSS in the drinking water. DSS was mainly observed in the Kupffer cells of the liver, in the macrophages of the mesenteric lymph node (MLN) and in the lamina propria of the large intestine after administration of DSS. We followed the time course of DSS distribution and found that DSS, which was considered as a large and negatively charged molecule that can not easily cross membranes, was distributed in the liver, the MLN, and the large intestine I day after the start of administration of DSS.

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页码：67 / 70

页数：4

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