Sexual Dysfunction in Type 2 Diabetes at Diagnosis: Progression over Time and Drug and Non-Drug Correlated Factors

被引:28
作者
Corona, Giovanni [1 ]
Giorda, Carlo B. [2 ]
Cucinotta, Domenico [3 ]
Guida, Piero [4 ]
Nada, Elisa [5 ]
机构
[1] Major Hosp, Endocrinol Unit, Bologna, Italy
[2] ASL Turin 5, Metab & Diabet Unit, Chieri, Italy
[3] Policl Messina, Dept Med, Messina, Italy
[4] Stat Consultant Assoc Med Diabetol, Rome, Italy
[5] Chaira Med Assoc, Chieri, Italy
关键词
LATE-ONSET HYPOGONADISM; REPORTED ERECTILE DYSFUNCTION; SILDENAFIL CITRATE VIAGRA(R); QUALITY-OF-LIFE; DOUBLE-BLIND; TESTOSTERONE SUPPLEMENTATION; CARDIOVASCULAR RISK; OLDER MEN; PREVALENCE; PARTNERS;
D O I
10.1371/journal.pone.0157915
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];
摘要
Aims To present the longitudinal data of the SUBITO-DE study, a prospective survey involving male patients with new or recently diagnosed type 2 diabetes mellitus (T2DM) (<24 months). Materials and Methods Sexual function was assessed in male patients with T2DM at baseline (phase 1) and after a mean follow-up of 18 months (phase 2). Standard metabolic parameters and sexual and depressive symptoms were evaluated. Results Six of the 499 enrolled patients died of different causes during phase 1. Of the 493 surviving men invited to participate in phase 2, 450 (mean age 59.0 +/- 9.0 years) (90.2%) accepted and 43 (8.2%) were lost to follow-up. As compared to baseline, the proportion of the men who reported improvement in erectile dysfunction (ED) at follow-up was nearly double that of the men who reported worsening of ED (22.6% vs. 12.8%). The increase in frequency of sexual activity the men reported at follow-up assessment indicates that many never treated before baseline were taking an ED drug during the study period (106 subjects). Phosphodiesterase type 5 inhibitors (PDE5i) were the ED drugs most commonly taken at both baseline and follow-up. An overall improvement over baseline values was observed in metabolic targets for T2DM and depressive symptoms. Conversely, no change in lifestyle behaviors was recorded during the study. Conclusions Sexual dysfunction is a major concern in men with T2DM. The SUBITO-DE study demonstrates that, when combined with adequate counseling and tailored PDE5i therapy, an integrated approach to achieving metabolic targets in men with T2DM can improve sexual function as well as depressive symptoms.
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页数:14
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