Induction of prophages of enterohemorrhagic Escherichia coli O157:H7 with norfloxacin

被引：117

作者：

Matsushiro, A ^{[1
]}

Sato, K

Miyamoto, H

Yamamura, T

Honda, T

机构：

[1] Kinki Univ, Dept Mol Genet, Sch Biol Oriented Sci & Technol, Wakayama 6496493, Japan

[2] Osaka Univ, Microbial Dis Res Inst, Osaka 5650871, Japan

来源：

JOURNAL OF BACTERIOLOGY | 1999年 / 181卷 / 07期

关键词：

D O I：

10.1128/JB.181.7.2257-2260.1999

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Norfloxacin (NFLX) caused induction of prophages VT1 and VT2 of enterohemorrhagic Escherichia coli O157 at subinhibitory concentrations. In time course experiments, we observed the folloing, sequential events: upon induction, the phage genomes underwent multiplication; the amount of sa genes increased; and subsequently, large quantities of toxins VT1 and VT2 were produced. Further studies showed that the molecular mechanism of prophage induction is closely related to the RecA system since the prophage VT2 was not induced with NFLX in a recA mutant strain.

引用

页码：2257 / 2260

页数：4

共 25 条

[1]

ALJUMAILI I, 1992, FEMS MICROBIOL LETT, V93, P121

[2] ESCHERICHIA-COLI RECA PROTEIN-DIRECTED CLEAVAGE OF PHAGE LAMBDA-REPRESSOR REQUIRES POLYNUCLEOTIDE [J].

CRAIG, NL ;

ROBERTS, JW .

NATURE, 1980, 283 (5742) :26-30

[3] NUCLEOTIDE-SEQUENCE AND PROMOTER MAPPING OF THE ESCHERICHIA-COLI SHIGA-LIKE TOXIN OPERON OF BACTERIOPHAGE-H-19B [J].

DEGRANDIS, S ;

GINSBERG, J ;

TOONE, M ;

CLIMIE, S ;

FRIESEN, J ;

BRUNTON, J .

JOURNAL OF BACTERIOLOGY, 1987, 169 (09) :4313-4319

[4] SITE OF ACTION OF A VERO TOXIN (VT2) FROM ESCHERICHIA-COLI O157-H7 AND OF SHIGA TOXIN ON EUKARYOTIC RIBOSOMES - RNA N-GLYCOSIDASE ACTIVITY OF THE TOXINS [J].

ENDO, Y ;

TSURUGI, K ;

YUTSUDO, T ;

TAKEDA, Y ;

OGASAWARA, T ;

IGARASHI, K .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1988, 171 (1-2) :45-50

[5]

HANNA WT, 1981, CANCER, V48, P2583, DOI 10.1002/1097-0142(19811215)48:12<2583::AID-CNCR2820481208>3.0.CO

[6]

2-6

[7]

HERSKOWITZ I, 1970, Journal of Molecular Biology, V47, P545, DOI 10.1016/0022-2836(70)90321-9

[8] ISOLATION AND CHARACTERIZATION OF NORFLOXACIN-RESISTANT MUTANTS OF ESCHERICHIA-COLI K-12 [J].

HIRAI, K ;

AOYAMA, H ;

SUZUE, S ;

IRIKURA, T ;

IYOBE, S ;

MITSUHASHI, S .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1986, 30 (02) :248-253

[9] SIGNAL-TRANSDUCTION RESPONSES FOLLOWING ADHESION OF VEROCYTOTOXIN-PRODUCING ESCHERICHIA-COLI [J].

ISMAILI, A ;

PHILPOTT, DJ ;

DYTOC, MT ;

SHERMAN, PM .

INFECTION AND IMMUNITY, 1995, 63 (09) :3316-3326

[10] GROWTH OF ESCHERICHIA-COLI IN THE PRESENCE OF TRIMETHOPRIM-SULFAMETHOXAZOLE FACILITATES DETECTION OF SHIGA-LIKE TOXIN PRODUCING STRAINS BY COLONY BLOT ASSAY [J].

KARCH, H ;

STROCKBINE, NA ;

OBRIEN, AD .

FEMS MICROBIOLOGY LETTERS, 1986, 35 (2-3) :141-145

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