Chromosomal mapping of five mouse G protein γ subunits

Heterotrimeric G proteins, composed of alpha, beta, and gamma subunits, transduce signals from transmembrane receptors to a wide range of intracellular effecters. The G protein gamma subunits, which play an indispensible role in this communication, constitute a large and diverse multigene family. Using an interspecific back cross panel, we have determined the mouse chromosomal locations of five gamma subunit genes: gamma 2, gamma 8, gamma 10, gamma 12, and gamma Cone. Combined with previous mapping studies, these data indicate that, with the possible exception of gamma 1 and gamma 11, the G protein gamma subunit genes are well dispersed within the mouse and human genomes. (C) 1999 Academic Press.