Protective effect of polysaccharides from morinda officinalis on bone loss in ovariectomized rats

被引：82

作者：

Zhu MengYong ^{[1
]}

Wang Caijiao ^{[1
]}

Zhang HuSheng ^{[2
]}

Pei XianWu ^{[3
]}

Fen JianMin ^{[2
]}

机构：

[1] Taizhou Cent Hosp, Dept Orthopaed, Taizhou 318000, Zhejiang, Peoples R China

[2] Shanghai RuiJing Hosp, Dept Orthopaed, Shanghai 200025, Peoples R China

[3] Beijing ShunYi Hosp, Dept Orthopaed, Beijing 100300, Peoples R China

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2008年 / 43卷 / 03期

关键词：

osteoporosis; rat; MOP; ovariectomy; bone mineral density;

D O I：

10.1016/j.ijbiomac.2008.06.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

In order to examine the effect of polysaccharides from morinda officinalis (MOP) on bone quality of osteoporosis rats. The osteoporosis in rats was induced by ovariectomy, and MOP (100 or 300 mg/kg) was orally administrated once daily. The animals were assessed 30 days after the operation for bone mineral density, serum cytokines level and mineral element concentration. MOP administration in rats resulted in an increase in bone mineral density and mineral element concentration, a decrease in serum cytokines level, which indicated that MOP administration may play an important role in the development of osteoporosis. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：276 / 278

页数：3

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