Pharmacology of bisphosphonates

被引：171

作者：

Cremers, Serge ^{[1
]}

Papapoulos, Socrates ^{[2
]}

机构：

[1] Columbia Univ Med Ctr, Dept Med, New York, NY 10032 USA

[2] Leiden Univ Med Ctr, Leiden, Netherlands

来源：

BONE | 2011年 / 49卷 / 01期

关键词：

Bisphosphonates; Pharmacokinetics; Pharmacodynamics; Review; BONE-MINERAL DENSITY; ZOLEDRONIC ACID; IN-VITRO; POSTMENOPAUSAL WOMEN; CANCER-PATIENTS; RENAL-FUNCTION; TC-99M DIPHOSPHONATE; GENERIC ALENDRONATE; BREAST-CANCER; PHARMACOKINETICS;

D O I：

10.1016/j.bone.2011.01.014

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Four decades of preclinical and clinical research of the pharmacology of bisphosphonates have generated data and concepts that have considerably improved their clinical use. However, despite this progress several pharmacological aspects relevant to bisphosphonate action on bone are still incompletely understood. This is mainly due to the complex, unique pharmacological properties of bisphosphonates. We review here the pharmacokinetic and pharmacodynamic data of bisphosphonates that are relevant for their clinical application and for the potential choice of a given compound, focusing on uncertainties that still exist. This article is part of a Special Issue entitled Bisphosphonates. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：42 / 49

页数：8

共 65 条

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ALENDRONATE DISTRIBUTED ON BONE SURFACES INHIBITS OSTEOCLASTIC BONE-RESORPTION IN-VITRO AND IN EXPERIMENTAL HYPERCALCEMIA MODELS [J].