Osmotic nephrosis: Acute kidney injury with accumulation of proximal tubular lysosomes due to administration of exogenous solutes

被引:207
作者
Dickenmann, Michael [1 ]
Oettl, Tobias [3 ]
Mihatsch, Michael J. [2 ]
机构
[1] Univ Basel Hosp, Clin Transplantat Immunol & Nephrol, CH-4031 Basel, Switzerland
[2] Univ Basel Hosp, Inst Pathol, CH-4031 Basel, Switzerland
[3] Univ Basel Hosp, Dept Internal Med, CH-4031 Basel, Switzerland
关键词
osmotic nephrosis; acute kidney injury;
D O I
10.1053/j.ajkd.2007.10.044
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Osmotic nephrosis describes a morphological pattern with vacuolization and swelling of the renal proximal tubular cells. The term refers to a nonspecific histopathologic finding rather than defining a specific entity. Osmotic nephrosis can be induced by many different compounds, such as sucrose, hydroxyethyl starch, dextrans, and contrast media. It has a broad clinical spectrum that includes acute kidney injury and chronic kidney failure in rare cases. This article discusses the pathological characteristics, pathogenesis, and various clinical entities of osmotic nephrosis.
引用
收藏
页码:491 / 503
页数:13
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