Synthesis of an orthogonally protected D-(+)-erythro-sphingosine

被引：14

作者：

Gargano, JM ^{[1
]}

Lees, WJ ^{[1
]}

机构：

[1] Syracuse Univ, Dept Chem, Syracuse, NY 13244 USA

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 34期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/S0040-4039(01)01152-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis presented provides rapid access to an orthogonally protected D-(+)-erythro-sphingosine: 1-methoxymethyl, 2-azido, 3-benzoyl. After selective deprotection the resulting sphingosine derivative is suitable for coupling to a wide variety of saccharides or other molecules at either the 1- or 3-position. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：5845 / 5847

页数：3

共 13 条

[1]

BELL RM, 1993, ADV LIPID RES SPHINO, V25, P26

[2]

Curfman C, 2000, METHOD ENZYMOL, V311, P391

[3]

DEVANT RM, 1992, KONTAKTE, P11

[4]

HANNUN YA, 1994, J BIOL CHEM, V269, P3125