Treatment of Parainfluenza 3 Infection With DAS181 in a Patient After Allogeneic Stem Cell Transplantation

被引：38

作者：

Chen, Yi-Bin ^{[1
]}

Driscoll, Jessica P. ^{[1
]}

McAfee, Steven L. ^{[1
]}

Spitzer, Thomas R. ^{[1
]}

Rosenberg, Eric S. ^{[2
]}

Sanders, Rebecca ^{[3
]}

Moss, Ronald B. ^{[3
]}

Fang, Fang ^{[3
]}

Marty, Francisco M. ^{[4
,5
]}

机构：

[1] Massachusetts Gen Hosp, Bone Marrow Transplant Unit, Boston, MA 02114 USA

[2] Massachusetts Gen Hosp, Div Infect Dis, Boston, MA 02114 USA

[3] NexBio, San Diego, CA USA

[4] Brigham & Womens Hosp, Div Infect Dis, Boston, MA 02115 USA

[5] Dana Farber Canc Inst, Boston, MA 02115 USA

来源：

CLINICAL INFECTIOUS DISEASES | 2011年 / 53卷 / 07期

关键词：

RESPIRATORY VIRUS-INFECTIONS; SIALIDASE FUSION PROTEIN; RECIPIENTS; DIAGNOSIS; THERAPY;

D O I：

10.1093/cid/cir501

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Parainfluenza virus (PIV) can cause significant morbidity after allogeneic stem cell transplantation (SCT). We report the first use of inhaled DAS181 for PIV in an allogeneic SCT recipient. Symptoms, oxygenation, and pulmonary function tests improved. Nasopharyngeal samples showed a reduction in viral load. DAS181 should be systematically evaluated for severe PIV infection.

引用

页码：E77 / E80

页数：4

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