Review of molecular modification techniques for improved detection of biomolecules by mass spectrometry

被引:22
作者
Honda, Aki [1 ,2 ]
Suzuki, Yoshio [3 ]
Suzuki, Koji [1 ,2 ]
机构
[1] Keio Univ, Dept Appl Chem, Kohoku Ku, Kanagawa 2238522, Japan
[2] Japan Sci & Technol, CREST, Kawaguchi, Saitama 3320012, Japan
[3] Tokyo Univ Technol, Res Ctr Adv Bion, Natl Inst Adv Ind Sci & Technol, Katayanagi Adv Res Labs, Tokyo 1920982, Japan
关键词
mass spectrometry; chemical modification; mass probe; biomolecules;
D O I
10.1016/j.aca.2008.05.064
中图分类号
O65 [分析化学];
学科分类号
070302 [分析化学]; 081704 [应用化学];
摘要
After a soft ionizing method was established, MS (mass spectrometry) has become a more common tool in biochemistry because soft ionization made it possible to detect large molecules such as proteins. Many kinds of applications were established to further utilize MS for the identification or quantitation of biomolecules. In this review, we introduce recent applications with special focus on chemical modification techniques and chemical probes developed for the MS determination of biomolecules. (C) 2008 Elsevier B.V. All rights reserved.
引用
收藏
页码:1 / 10
页数:10
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