Anticancer activity and biophysical reactivity of copper complexes of 2-(benzo[d][1,3]dioxol-5-ylmethylene)-N-alkylhydrazinecarbothioamides

被引：28

作者：

Beckford, Floyd A. ^{[1
]}

Thessing, Jeffrey ^{[1
]}

Stott, Alyssa ^{[1
]}

Holder, Alvin A. ^{[2
]}

Poluektov, Oleg G. ^{[3
]}

Li, Liya ^{[4
]}

Seeram, Navindra P. ^{[4
]}

机构：

[1] Lyon Coll, Div Sci, Batesville, AR 72501 USA

[2] Univ So Mississippi, Dept Chem & Biochem, Hattiesburg, MS 39406 USA

[3] Argonne Natl Lab, Chem Sci & Engn Div, Argonne, IL 60439 USA

[4] Univ Rhode Isl, Bioact Bot Res Lab, Dept Biomed & Pharmaceut Sci, Kingston, RI 02881 USA

来源：

INORGANIC CHEMISTRY COMMUNICATIONS | 2012年 / 15卷

基金：

美国国家科学基金会;

关键词：

Human serum albumin; Thiosemicarbazones; Anticancer; DNA binding; Structural variation; TRANSITION-METAL-COMPLEXES; DNA-BINDING; THIOSEMICARBAZONE COMPLEXES; AGENTS;

D O I：

10.1016/j.inoche.2011.10.032

中图分类号：

O61 [无机化学];

学科分类号：

070301 [无机化学];

摘要：

A series of copper complexes were synthesized from benzo[d][1,3]dioxole-5-carbaldehyde (piperonal) thiosemicarbazones (RHpTSC where R = H, CH3, C2H5 or C6H5 (Ph)). The complexes show interesting variations in geometry depending on the thiosemicarbazone; a dinuclear complex [Cu(HpTSC)Cl]2, a mononuclear complex [Cu(RHpTSC)2Cl2] (R = CH3 or C2H5) and another mononuclear complex [Cu(PhHpTSC)(PhpTSC)Cl] was generated. The complexes bind in a moderately strong fashion to DNA with binding constants on the order of 10(4)M(-1). They are also strong binders of human serum albumin with binding constants near 10(4) M-1. The complexes show good in vitro cytotoxic profiles against two human colon cancer cell lines (HT-116 and HT29) and two human breast cancer cell lines (MCF-7 and MDA-MB-231) with IC50 values in the low millimolar concentration range. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：225 / 229

页数：5

共 27 条

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Transition metal complexes of phenanthrenequinone thiosemicarbazone as potential anticancer agents: synthesis, structure, spectroscopy, electrochemistry and in vitro anticancer activity against human breast cancer cell-line, T47D [J].