Chromosomal radiosensitivity in patients with common variable immunodeficiency

被引：48

作者：

Aghamohammadi, Asghar ^{[1
]}

Moin, Mostafa ^{[1
]}

Kouhia, Ali ^{[1
]}

Mohagheghi, Mohammad-Ali ^{[2
]}

Shirazi, Alireza ^{[3
]}

Rezaei, Nima ^{[1
]}

Tavassoli, Sanaz ^{[1
]}

Esfahani, Mahbod ^{[4
]}

Cheraghi, Taher ^{[1
]}

Dastan, Jila ^{[5
]}

Nersesian, Jeanet ^{[5
]}

Ghaffari, Saeed Reza ^{[5
,6
]}

机构：

[1] Med Sci Univ Tehran, Immunol Asthma & Allergy Res Inst, Childrens Med Ctr, Dept Allergy & Clin Immunol, Tehran, Iran

[2] Med Sci Univ Tehran, Canc Res Inst, Tehran, Iran

[3] Med Sci Univ Tehran, Fac Med, Dept Biophys, Tehran, Iran

[4] Med Sci Univ Tehran, Inst Canc, Dept Radiotherapy, Tehran, Iran

[5] Gene Inst, Tehran, Iran

[6] Med Sci Univ Tehran, Canc Res Ctr, Dept Genet & Genom, Tehran, Iran

来源：

IMMUNOBIOLOGY | 2008年 / 213卷 / 05期

关键词：

cancer; chromosome aberrancy; common variable immunodeficiency; primary immunodeficiency disorders; radiosensitivity;

D O I：

10.1016/j.imbio.2007.10.018

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

Common variable immunodeficiency (CVID) is a heterogeneous group of primary immunodeficiency disorders. In addition to recurrent infections and autoimmunity, cancers are more prevalent in these patients than the normal population. Increased radiosensitivity may be a reason for the increased malignancies. To analyze chromosomal radiosensitivity of CVID patients, lymphocytes were cultured from 20 CVID patients. After irradiation (50, 100 cGy), metaphases were evaluated for chromosomal aberrations. Results were compared in patients, healthy individuals, and ataxia telangiectasia as positive controls. Before irradiation there was no difference between groups of patients, but after radiation, the incidence of all kinds of aberrations was higher in the CVID patients and. this was statistically significant at 100cGy (P < 0.05). CVID patients appear to be susceptible to in vitro irradiation. These patients should be protected from unnecessary radiographic diagnostic and therapeutic procedures. Also, radiosensitivity may help classifying CVID patients. (c) 2007 Elsevier GmbH. All rights reserved.

引用

页码：447 / 454

页数：8

共 45 条

[1]

Clinical and immunological features of 65 Iranian patients with common variable immunodeficiency [J].