Evaluation of Scaffolds based on α-Tricalcium Phosphate Cements for Tissue Engineering Applications

被引：9

作者：

de Moraes Machado, Jeferson L. ^{[1
]}

Giehl, Isabel Cristina

Nardi, Nance B.

dos Santos, Luis A. ^{[1
]}

机构：

[1] Univ Fed Rio Grande do Sul, Dept Mat Engn, BR-91501110 Porto Alegre, RS, Brazil

来源：

IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING | 2011年 / 58卷 / 06期

关键词：

Forchheimer equation; scaffolds; tricalcium phosphate cement;

D O I：

10.1109/TBME.2011.2117425

中图分类号：

R318 [生物医学工程];

学科分类号：

100103 [病原生物学];

摘要：

Growth of cells in 3-D porous scaffolds has gained importance in the field of tissue engineering. The scaffolds guide cellular growth, synthesize extracellular matrix and other biological molecules, and make the formation of tissues and functional organs easier. The aim of this study is to use a-tricalcium phosphate cement in order to obtain new types of scaffolds with the aid of paraffin spheres as pore generators. The porosity of the scaffolds produced with paraffin spheres was analyzed and compared to the literature, and the study of scaffold permeability using the Forchheimer equation allowed the analysis of pore interconnectivity. In vitro tests showed the behavior of scaffolds in solutions of simulated body fluid, and viability and cell proliferation were also evaluated. The results show the potential use of the materials developed for scaffolds for use in tissue engineering applications.

引用

页码：1814 / 1819

页数：6

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