Reprograming T cells: the role of extracellular matrix in coordination of T cell activation and migration

被引：96

作者：

Dustin, ML

de Fougerolles, AR

机构：

[1] NYU, Sch Med, Skirball Inst Mol Med, Mol Pathogenesis Program, New York, NY 10016 USA

[2] NYU, Sch Med, Dept Pathol, New York, NY 10016 USA

[3] Biogen Inc, Cambridge, MA 02142 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2001年 / 13卷 / 03期

关键词：

D O I：

10.1016/S0952-7915(00)00217-X

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

The stable immunological synapse between a T cell and antigen-presenting cell coordinates migration and activation. Three-dimensional collagen gels transform this interaction into a series of transient hit-and-run encounters. Here we integrate these alternative modes of interaction in a model for primary T cell activation and effector function in vivo.

引用

收藏

页码：286 / 290

页数：5

相关论文

共 38 条

[1]

Engagement of the α2β1 integrin inhibits Fas ligand expression and activation-induced cell death in T cells in a focal adhesion kinase-dependent manner [J].

Aoudjit, F ;

Vuori, K .

BLOOD, 2000, 95 (06) :2044-2051

[2]

EXPRESSION AND FUNCTIONS OF VERY LATE ANTIGEN-1 IN INFLAMMATORY JOINT DISEASES [J].

BANK, I ;

ROTH, D ;

BOOK, M ;

GUTERMAN, A ;

SHNIRRER, I ;

BLOCK, R ;

EHRENFELD, M ;

LANGEVITZ, P ;

BRENNER, H ;

PRAS, M .

JOURNAL OF CLINICAL IMMUNOLOGY, 1991, 11 (01) :29-38

[3]

Cutting edge: Hierarchy of chemokine receptor and TCR signals regulating T cell migration and proliferation [J].

Bromley, SK ;

Peterson, DA ;

Gunn, MD ;

Dustin, ML .

JOURNAL OF IMMUNOLOGY, 2000, 165 (01) :15-19

[4]

Isolation, cloning, and sequence analysis of the integrin subunit α10, a β1-associated collages binding integrin expressed on chondrocytes [J].

Camper, L ;

Hellman, U ;

Lundgren-Åkerlund, E .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (32) :20383-20389

[5]

DISTINCT CELLULAR FUNCTIONS MEDIATED BY DIFFERENT VLA INTEGRIN ALPHA-SUBUNIT CYTOPLASMIC DOMAINS [J].

CHAN, BM ;

KASSNER, PD ;

SCHIRO, JA ;

BYERS, HR ;

KUPPER, TS ;

HEMLER, ME .

CELL, 1992, 68 (06) :1051-1060

[6]

Regulation of inflammation by collagen-binding integrins α1β1 and α2β1 in models of hypersensitivity and arthritis [J].

de Fougerolles, AR ;

Sprague, AG ;

Nickerson-Nutter, CL ;

Chi-Rosso, G ;

Rennert, PD ;

Gardner, H ;

Gotwals, PJ ;

Lobb, RR ;

Koteliansky, VE .

JOURNAL OF CLINICAL INVESTIGATION, 2000, 105 (06) :721-729

[7]

The immunological synapse and the actin cytoskeleton: molecular hardware for T cell signaling [J].

Dustin, ML ;

Cooper, JA .

NATURE IMMUNOLOGY, 2000, 1 (01) :23-29

[8]

Signaling takes shape in the immune system [J].

Dustin, ML ;

Chan, AC .

CELL, 2000, 103 (02) :283-294

[9]

A novel adaptor protein orchestrates receptor patterning and cytoskeletal polarity in T-cell contacts [J].

Dustin, ML ;

Olszowy, MW ;

Holdorf, AD ;

Li, J ;

Bromley, S ;

Desai, N ;

Widder, P ;

Rosenberger, F ;

van der Merwe, PA ;

Allen, PM ;

Shaw, AS .

CELL, 1998, 94 (05) :667-677

[10]

Orchestrated information transfer underlying leukocyte endothelial interactions [J].

Ebnet, K ;

Kaldjian, EP ;

Anderson, AO ;

Shaw, S .

ANNUAL REVIEW OF IMMUNOLOGY, 1996, 14 :155-177

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