Cell-Cycle Proteins Control Production of Neutrophil Extracellular Traps

被引：228

作者：

Amulic, Borko ^{[1
]}

Knackstedt, Sebastian Lorenz ^{[1
]}

Abu Abed, Ulrike ^{[1
,2
]}

Deigendesch, Nikolaus ^{[1
,3
]}

Harbort, Christopher J. ^{[1
]}

Caffrey, Brian E. ^{[4
]}

Brinkmann, Volker ^{[2
]}

Heppner, Frank L. ^{[3
,5
,6
,7
]}

Hinds, Philip W. ^{[8
]}

Zychlinsky, Arturo ^{[1
]}

机构：

[1] Max Planck Inst Infect Biol, Dept Cellular Microbiol, D-10117 Berlin, Germany

[2] Max Planck Inst Infect Biol, Microscopy Core Facil, D-10117 Berlin, Germany

[3] Charite, Dept Neuropathol, D-10117 Berlin, Germany

[4] Max Planck Inst Mol Genet, D-14195 Berlin, Germany

[5] NeuroCure, Cluster Excellence, D-10117 Berlin, Germany

[6] BIH, D-10178 Berlin, Germany

[7] German Ctr Neurodegenerat Dis DZNE, D-10117 Berlin, Germany

[8] Tufts Univ, Sch Med, Dept Dev Mol & Chem Biol, Boston, MA 02111 USA

来源：

DEVELOPMENTAL CELL | 2017年 / 43卷 / 04期

关键词：

DEPENDENT KINASE 6; CYTOKINE PRODUCTION; CDK6; MYELOPEROXIDASE; CANDIDIASIS; MECHANISMS; RELEASE; INNATE; CANCER; DEATH;

D O I：

10.1016/j.devcel.2017.10.013

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Neutrophils are essential for immune defense and can respond to infection by releasing chromatin in the form of neutrophil extracellular traps (NETs). Here we show that NETs are induced by mitogens and accompanied by induction of cell-cycle markers, including phosphorylation of the retinoblastoma protein and lamins, nuclear envelope breakdown, and duplication of centrosomes. We identify cyclindependent kinases 4 and 6 (CDK4/6) as essential regulators of NETs and show that the response is inhibited by the cell-cycle inhibitor p21 Cip. CDK6, in neutrophils, is required for clearance of the fungal pathogen Candida albicans. Our data describe a function for CDK4/6 in immunity.

引用

页码：449 / +

页数：19

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