Dendritic Cell and Macrophage Heterogeneity In Vivo

被引：322

作者：

Hashimoto, Daigo ^{[1
,2
]}

Miller, Jennifer ^{[1
,2
]}

Merad, Miriam ^{[1
,2
,3
]}

机构：

[1] Mt Sinai Sch Med, Dept Oncol Sci, New York, NY 10029 USA

[2] Mt Sinai Sch Med, Inst Immunol, New York, NY 10029 USA

[3] Mt Sinai Sch Med, Tisch Canc Inst, New York, NY 10029 USA

来源：

IMMUNITY | 2011年 / 35卷 / 03期

基金：

美国国家卫生研究院;

关键词：

COLONY-STIMULATING FACTOR; PERIPHERAL LYMPHOID ORGANS; SUBCAPSULAR SINUS MACROPHAGES; STEADY-STATE CONDITIONS; MOUSE BONE-MARROW; LANGERHANS CELLS; FUNCTIONAL-PROPERTIES; ANTIGEN-PRESENTATION; CROSS-PRESENTATION; RETINOIC-ACID;

D O I：

10.1016/j.immuni.2011.09.007

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Macrophage and dendritic cell (DC) are hematopoietic cells found in all tissues in the steady state that share the ability to sample the environment but have distinct function in tissue immunity. Controversies remain on the best way to distinguish macrophages from DCs in vivo. In this Perspective, we discuss how recent discoveries in the origin of the DC and macrophage lineage help establish key functional differences between tissue DC and macrophage subsets. We also emphasize the need to further understand the functional heterogeneity of the tissue DC and macrophage lineages to better comprehend the complex role of these cells in tissue homeostasis and immunity.

引用

页码：323 / 335

页数：13

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