Chemistry and the missing era of evolution

被引：35

作者：

Cairns-Smith, A. Graham ^{[1
]}

机构：

[1] Univ Glasgow, Dept Chem, Glasgow G12 8QQ, Lanark, Scotland

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2008年 / 14卷 / 13期

关键词：

chemical biology; crystal growth; directed evolution; enzymes; inorganic chemistry;

D O I：

10.1002/chem.200701215

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The Darwinian evolution of life on earth depends utterly on complex molecular machinery, which, it seems, could only have arisen through a Darwinian evolution. The "RNA world" idea reduces this paradox, but requires a geochemically implausible supply of RNA monomers. A pre-RNA era of natural selection is implied. I suggest that originally this was based on inorganic materials that came to replicate permutations with specific (e.g. catalytic) effects.

引用

页码：3830 / 3839

页数：10

共 67 条

[1] Nuclear quantum effects and enzyme dynamics in dihydrofolate reductase catalysis [J].

Agarwal, PK ;

Billeter, SR ;

Hammes-Schiffer, S .

JOURNAL OF PHYSICAL CHEMISTRY B, 2002, 106 (12) :3283-3293

[2] Network of coupled promoting motions in enzyme catalysis [J].

Agarwal, PK ;

Billeter, SR ;

Rajagopalan, PTR ;

Benkovic, SJ ;

Hammes-Schiffer, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (05) :2794-2799

[3]

[Anonymous], 2006, PHILOS T R SOC B, V361, P1293

[4] Conformation coupled enzyme catalysis: Single-molecule and transient kinetics investigation of dihydrofolate reductase [J].

Antikainen, NM ;

Smiley, RD ;

Benkovic, SJ ;

Hammes, GG .

BIOCHEMISTRY, 2005, 44 (51) :16835-16843

[5] Barrier passage and protein dynamics in enzymatically catalyzed reactions [J].

Antoniou, D ;

Caratzoulas, S ;

Kalyanaraman, C ;

Mincer, JS ;

Schwartz, SD .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 2002, 269 (13) :3103-3112

[6] Computational and theoretical methods to explore the relation between enzyme dynamics and catalysis [J].

Antoniou, Dimitri ;

Basner, Jodi ;

Nunez, Sara ;

Schwartz, Steven D. .

CHEMICAL REVIEWS, 2006, 106 (08) :3170-3187

[7] The complete atomic structure of the large ribosomal subunit at 2.4 Å resolution [J].

Ban, N ;

Nissen, P ;

Hansen, J ;

Moore, PB ;

Steitz, TA .

SCIENCE, 2000, 289 (5481) :905-920

[8]

BARONNET A, 1997, MODULAR ASPECTS MINE, V1, P119

[9] A perspective on enzyme catalysis [J].

Benkovic, SJ ;

Hammes-Schiffer, S .

SCIENCE, 2003, 301 (5637) :1196-1202

[10] Understanding nucleic acids using synthetic chemistry [J].

Benner, SA .

ACCOUNTS OF CHEMICAL RESEARCH, 2004, 37 (10) :784-797

← 1 2 3 4 5 6 7 →