The discovery of placenta growth factor and its biological activity

被引：352

作者：

De Falco, Sandro ^{[1
,2
]}

机构：

[1] CNR, Angiogenesis Lab, Inst Genet & Biophys Adriano Buzzati Traverso, I-80131 Naples, Italy

[2] CNR, Stem Cell Fate Lab, Inst Genet & Biophys Adriano Buzzati Traverso, I-80131 Naples, Italy

来源：

EXPERIMENTAL AND MOLECULAR MEDICINE | 2012年 / 44卷 / 01期

关键词：

angiogenesis inducing agents; anoxia; endothelial cells; hypoxia; macrophages; neovascularization; pathologic; placenta growth factor; vascular endothelial growth factors; BONE-MARROW MICROENVIRONMENT; HYPOXIA-INDUCIBLE FACTOR-1; ADIPOSE-TISSUE DEVELOPMENT; ALPHA-CONVERTING ENZYME; FACTOR GENE-EXPRESSION; TRANSCRIPTION FACTOR-I; 5 UNTRANSLATED REGION; ENDOTHELIAL-CELLS; CRYSTAL-STRUCTURE; CARDIAC-HYPERTROPHY;

D O I：

10.3858/emm.2012.44.1.025

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Angiogenesis is a complex biological phenomenon crucial for a correct embryonic development and for post-natal growth. In adult life, it is a tightly regulated process confined to the uterus and ovary during the different phases of the menstrual cycle and to the heart and skeletal muscles after prolonged and sustained physical exercise. Conversly, angiogenesis is one of the major pathological changes associated with several complex diseases like cancer, atherosclerosis, arthritis, diabetic retinopathy and age-related macular degeneration. Among the several molecular players involved in angiogenesis, some members of VEGF family, VEGF-A, VEGF-B and placenta growth factor (PIGF), and the related receptors VEGF receptor 1 (VEGFR-1, also known as Flt-1) and VEGF receptor 2 (VEGFR-2, also known as Flk-1 in mice and KDR in human) have a decisive role. In this review, we describe the discovery and molecular characteristics of PIGF, and discuss the biological role of this growth factor in physiological and pathological conditions.

引用

页码：1 / 9

页数：9

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