The Selective Metabotropic Glutamate 2/3 Receptor Agonist MG50028 Reverses Isolation Rearing Induced Abnormal Behaviors in Mice

被引：26

作者：

Ago, Yukio ^{[1
]}

Araki, Ryota ^{[1
]}

Yano, Koji ^{[1
]}

Kawasaki, Toshiyuki ^{[3
]}

Chaki, Shigeyuki ^{[4
]}

Nakazato, Atsuro ^{[5
]}

Onoe, Hirotaka ^{[3
]}

Hashimoto, Hitoshi ^{[2
,6
,7
,8
]}

Baba, Akemichi ^{[2
,9
]}

Takuma, Kazuhiro ^{[1
]}

Matsuda, Toshio ^{[1
,6
,7
]}

机构：

[1] Osaka Univ, Grad Sch Pharmaceut Sci, Lab Med Pharmacol, Suita, Osaka 5650871, Japan

[2] Osaka Univ, Grad Sch Pharmaceut Sci, Lab Mol Neuropharmacol, Suita, Osaka 5650871, Japan

[3] Kobe MI R&D Ctr, Ctr Mol Imaging Sci, RIKEN, Funct Probe Res Lab,Chuo Ku, Kobe, Hyogo 6500047, Japan

[4] Taisho Pharmaceut Co Ltd, Mol Funct & Pharmacol Labs, Kita Ku, Saitama 3319530, Japan

[5] Taisho Pharmaceut Co Ltd, R&D Headquarters Pharmaceut Operat, Strateg Planning Drug Discovery, Kita Ku, Saitama 3319530, Japan

[6] Kanazawa Univ, Osaka Univ, United Grad Sch Child Dev, Suita, Osaka 5650871, Japan

[7] Osaka Univ, Hamamatsu Univ Sch Med, Suita, Osaka 5650871, Japan

[8] Osaka Univ, Grad Sch Med, Dept Mol Pharmaceut Sci, Suita, Osaka 5650871, Japan

[9] Hyogo Univ Hlth Sci, Chuo Ku, Kobe, Hyogo 6508530, Japan

来源：

JOURNAL OF PHARMACOLOGICAL SCIENCES | 2012年 / 118卷 / 02期

关键词：

metabotropic glutamate 2/3 receptor; isolation rearing; behavior; WEANING SOCIAL-ISOLATION; SCHIZOPHRENIA; PHENCYCLIDINE; PHASE-2; DRUG;

D O I：

10.1254/jphs.11200SC

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Isolation-induced abnormal behaviors are useful animal models for assessing potential anti-psychotic drugs. This study examined the effect of MGS0028, a selective metabotropic glutamate 2/3 receptor agonist, on abnormal behaviors such as hyperactivity, aggression, and deficits of prepulse inhibition in isolation-reared mice. MGS0028 attenuated hyperactivity and aggressive behaviors in isolation-reared mice. The agonist also reversed isolation rearing induced deficits of prepulse inhibition. On the other hand, MGS0028 did not affect locomotor activity and prepulse inhibition in group-reared mice. These results suggest that the metabotropic glutamate 2/3 receptor agonist, MGS0028, is a potential compound for the treatment of psychiatric disorders.

引用

页码：295 / 298

页数：4

共 16 条

[1]

Activation of metabotropic glutamate 2/3 receptors attenuates methamphetamine-induced hyperlocomotion and increase in prefrontal serotonergic neurotransmission [J].