EbpR is important for biofilm formation by activating expression of the endocarditis and biofilm-associated pilus operon (ebpABC) of Enterococcus faecalis OG1RF

被引：44

作者：

Bourgogne, Agathe

Singh, Kavindra V.

Fox, Kristina A.

Pflughoeft, Kathryn J.

Murray, Barbara E.

Garsin, Danielle A.

机构：

[1] Univ Texas, Sch Med, Div Infect Dis, Ctr Study Emerging & Reemerging Pathogens, Houston, TX 77030 USA

[2] Univ Texas, Sch Med, Div Infect Dis, Dept Med, Houston, TX 77030 USA

[3] Univ Texas, Sch Med, Dept Microbiol & Mol Genet, Houston, TX 77030 USA

来源：

JOURNAL OF BACTERIOLOGY | 2007年 / 189卷 / 17期

关键词：

GRAM-POSITIVE BACTERIA; SERINE-PROTEASE; CONSTRUCTION; GELATINASE; SYSTEM; GENES;

D O I：

10.1128/JB.00594-07

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We identify ef1090 (renamed ebpR) and show its importance for the transcriptional regulation of expression of the Enterococcus faecalis pilus operon, ebpABC. An ebpR deletion (Delta ebpR) mutant was found to have reduced ebpABC expression with loss of pilus production and a defect in primary adherence with, as a consequence, reduced biofilm formation.

引用

页码：6490 / 6493

页数：4

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